Regulus is the alpha star in the constellation of Leo, and lies at a distance of approx. 72.4 LY. During the Age of Leo, 13500 years ago, the sun rose over Regulus in the Northern hemisphere on the vernal equinox. The sphinx of Giza was aligned with this phenomenon. By 2300 BC, the sun went over Regulus at midday on the summer solstice.
Astronomically speaking, Regulus is the star that comes closest to the point where the ecliptic of the zodiac (i.e. the celestial zero longitude meridian, based upon the middle of the milky way) and the celestial equator (i.e. the celestial zero latitude meridian, parallel to the equator of the Earth and the sun) cross.
Underneath Regulus is a star Wolf 359 from which radio signals have been picked up that could indicate the presence of intelligent life. Wolf 359 is the third closest star system, after Centauri and Barnard's star. (Which makes it closer than even Sirius).
Persian mythology: Regulus is one of 4 royal stars.
According to Bantu Mythology mankind is not indigenous to planet Earth. Along with Sirius and Orion, Regulus would be one of the star systems from which man originates. It would also be the star system from which the lions and the lion Gods (half man, half human) originally came.
[Note: thus far, I could not find confirmation on that. According to the information I have "Cat-people," both the Bastet and Sekhmet type, would come from the Lyran system.]
In Chinese mythology / history, the legendary Yellow Emperor, Huang-Ti, who lived around 2700 BC and under whose reign, acupuncture, agriculture and the Chinese alphabet were introduced, would have come from Regulus. At the end of his life he is said to have returned to Regulus.